Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression

被引：61

作者：

Bai, Yanhua ^{[1
,2
]}

Kakudo, Kennichi ^{[1
]}

Nakamura, Misa ^{[1
,3
]}

Ozaki, Takashi ^{[1
]}

Li, Yaqiong ^{[1
,2
]}

Liu, Zhiyan ^{[1
,2
]}

Mori, Ichiro ^{[1
]}

Miyauchi, Akira ^{[4
]}

Zhou, Gengyin ^{[2
]}

机构：

[1] Wakayama Med Univ, Dept Pathol, Wakayama 6418509, Japan

[2] Shandong Univ, Sch Med, Dept Pathol & Pothophysiol, Jinan 250012, Shandong, Peoples R China

[3] Osaka Kawasaki Rehabil Univ, Dept Rehabil, Osaka 5970104, Japan

[4] Kuma Hosp, Dept Surg, Chuo Ku, Kobe, Hyogo 6500011, Japan

来源：

CANCER LETTERS | 2009年 / 281卷 / 02期

关键词：

Cohesiveness; Epithelial-mesenchymal transition; Periostin; Thyroid carcinoma; Polarity; TO-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; GENE-EXPRESSION; FASCICLIN-I; ADHESION MOLECULE; SEQUENCE-ANALYSIS; BREAST-CANCER; ORAL-CANCER; COMMON TYPE; RISK GROUP;

D O I：

10.1016/j.canlet.2009.02.043

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Loss of cellular polarity/cohesiveness and periostin expression are involved in the epithelial-mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma were studied. There was a significant correlation between the loss of cellular polarity/cohesiveness in the invasive front and the up-regulation of periostin in tumors. Both of them were significantly correlated with extrathyroid invasion, pT and lymph node metastasis. Our results suggest that the loss of cellular polarity/cohesiveness is a useful parameter for predicting prognosis of patients with papillary thyroid carcinoma, and periostin could be a candidate gene for therapeutic targeting for the blockage of tumor invasion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：188 / 195

页数：8

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