Generation of neuronal variability and complexity

被引：186

作者：

Muotri, Alysson R. ^{[1
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

NATURE | 2006年 / 441卷 / 7097期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature04959

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The production of specialized differentiated neurons derived from stem cells has been proposed as a revolutionary technology for regenerative medicine. However, few examples of specific neuronal cell differentiation have been described so far. Although stem-cell tissue replacement might be seemingly straightforward in other cases, the high degree of complexity of the nervous system raises the challenge of tissue replacement substantially. Understanding mechanisms of neuronal diversification will not only be relevant for therapeutic purposes but might also shed light on the differences in cognitive abilities, personality traits and psychiatric conditions observed in humans.

引用

页码：1087 / 1093

页数：7

共 96 条

[1] ON SOMATIC RECOMBINATION IN THE CENTRAL-NERVOUS-SYSTEM OF TRANSGENIC MICE [J].

ABELIOVICH, A ;

GERBER, D ;

TANAKA, O ;

KATSUKI, M ;

GRAYBIEL, AM ;

TONEGAWA, S .

SCIENCE, 1992, 257 (5068) :404-408

[2] EDITING FOR AN AMPA RECEPTOR SUBUNIT RNA IN PREFRONTAL CORTEX AND STRIATUM IN ALZHEIMERS-DISEASE, HUNTINGTONS-DISEASE AND SCHIZOPHRENIA [J].

AKBARIAN, S ;

SMITH, MA ;

JONES, EG .

BRAIN RESEARCH, 1995, 699 (02) :297-304

[3] TIME OF NEURON ORIGIN IN DIENCEPHALON OF MOUSE - AN AUTORADIOGRAPHIC STUDY [J].

ANGEVINE, JB .

JOURNAL OF COMPARATIVE NEUROLOGY, 1970, 139 (02) :129-&

[4] Regulation of gene expression by alternative promoters [J].

Ayoubi, TAY ;

VanDeVen, WJM .

FASEB JOURNAL, 1996, 10 (04) :453-460

[5] Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation [J].

Balmer, D ;

Goldstine, J ;

Rao, YM ;

LaSalle, JM .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2003, 81 (01) :61-68

[6] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[7] LINE-1 RNA splicing and influences on mammalian gene expression [J].

Belancio, VP ;

Hedges, DJ ;

Deininger, P .

NUCLEIC ACIDS RESEARCH, 2006, 34 (05) :1512-1521

[8] Mechanisms of alternative pre-messenger RNA splicing [J].

Black, DL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :291-336

[9] Epigenetic control of neurobehavioural plasticity: the role of neurotrophins [J].

Branchi, I ;

Francia, N ;

Alleva, E .

BEHAVIOURAL PHARMACOLOGY, 2004, 15 (5-6) :353-362

[10] Neural representations in human spatial memory [J].

Burgess, N ;

O'Keefe, J .

TRENDS IN COGNITIVE SCIENCES, 2003, 7 (12) :517-519

← 1 2 3 4 5 6 7 8 9 10 →