Issues related to targeted delivery of proteins and peptides

被引：74

作者：

Lu, Yingjuan

Yang, Jun

Sega, Emanuela

机构：

[1] Endocyte Inc, W Lafayette, IN 47906 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

AAPS JOURNAL | 2006年 / 8卷 / 03期

关键词：

targeted delivery; protein therapeutics; peptide therapeutics; cancer therapy;

D O I：

10.1208/aapsj080355

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site-specific pharmacological actions. This article discusses the issues associated with targeted delivery of protein and peptide drugs at physiochemical, physiological, and intracellular levels with a special focus on cancer therapy.

引用

页码：E466 / E478

页数：13

共 113 条

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