Tissue tropism of a Thailand strain of high-pathogenicity avian influenza virus (H5N1) in tissues of naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anas spp.)

被引:35
作者
Antarasena, Chongmas [1 ]
Sirimujalin, Rungtiva
Prommuang, Porntip
Blacksell, Stuart D.
Promkuntod, Naruepol
Prommuang, Praison
机构
[1] So Vet Res & Diagnost Ctr, Nakhon Si Thammarat 80110, Thailand
[2] Mahidol Univ, Fac Vet Sci, Phuttamonthon 73170, Nakornpathom, Thailand
[3] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand
[4] Univ Oxford, Churchill Hosp, Nuffield Dept Clin Med, Ctr Clin Vaccinol & Trop Med, Oxford OX1 2JD, England
基金
英国惠康基金;
关键词
D O I
10.1080/03079450600714510
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The tropism of a Thailand strain of highly pathogenic avian influenza H5N1 virus was demonstrated on tissues ( lung, trachea, heart, liver, spleen, pancreas, rectum, kidney, brain, skeletal muscle, duodenum, and oviduct) from naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anas spp.) by indirect immunofluorescence assay. In chickens and quail, the distribution and localization of nucleoprotein viral antigen was similar and detected at the highest level in cardiac myocytes, at 88% (chickens) and 89% (quail), and respiratory, digestive and urinary systems all showed high levels of antigen. Antigen in duck tissues were detected at significantly lower levels (P < 0.05) with the exception of brain and skeletal muscle samples. In most cases, antigen in duck tissue was absent in the digestive organs but present in respiratory organs, which supports the hypothesis that aerosol and oral-oral transmission are the main method of highly pathogenic avian influenza virus transmission from this species.
引用
收藏
页码:250 / 253
页数:4
相关论文
共 14 条
[1]   Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia [J].
Hulse-Post, DJ ;
Sturm-Ramirez, KM ;
Humberd, J ;
Seiler, P ;
Govorkova, EA ;
Krauss, S ;
Scholtissek, C ;
Puthavathana, P ;
Buranathai, C ;
Nguyen, TD ;
Long, HT ;
Naipospos, TSP ;
Chen, H ;
Ellis, TM ;
Guan, Y ;
Peiris, JSM ;
Webster, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10682-10687
[2]   Highly pathogenic avian influenza (H5N1) in the commercial domestic ducks of South Korea [J].
Kwon, YK ;
Joh, SJ ;
Kim, MC ;
Sung, HW ;
Lee, YJ ;
Choi, JG ;
Lee, EK ;
Kim, JH .
AVIAN PATHOLOGY, 2005, 34 (04) :367-370
[3]   Characterization of highly pathogenic H5N1 avian influenza A viruses isolated from South Korea [J].
Lee, CW ;
Suarez, DL ;
Tumpey, TM ;
Sung, HW ;
Kwon, YK ;
Lee, YJ ;
Choi, JG ;
Joh, SJ ;
Kim, MC ;
Lee, EK ;
Park, JM ;
Lu, XH ;
Katz, JM ;
Spackman, E ;
Swayne, DE ;
Kim, JH .
JOURNAL OF VIROLOGY, 2005, 79 (06) :3692-3702
[4]   Epidemiology, pathology, and immunohistochemistry of layer hens naturally affected with H5N1 highly pathogenic avian influenza in Japan [J].
Nakatani, H ;
Nakamura, M ;
Yamamoto, Y ;
Yamada, M ;
Yamamoto, Y .
AVIAN DISEASES, 2005, 49 (03) :436-441
[5]  
*OFF INT EP, 2004, MAN DIAGN TESTS VACC, P258
[6]  
Perkins LEL, 2002, AVIAN DIS, V46, P53, DOI 10.1637/0005-2086(2002)046[0053:POAHKO]2.0.CO
[7]  
2
[8]   Pathobiology of A/Chicken/Hong Kong/220/97 (H5N1) avian influenza virus in seven Gallinaceous species [J].
Perkins, LEL ;
Swayne, DE .
VETERINARY PATHOLOGY, 2001, 38 (02) :149-164
[9]   Characterization of avian H5N1 influenza viruses from poultry in Hong Kong [J].
Shortridge, KF ;
Zhou, NN ;
Guan, Y ;
Gao, P ;
Ito, T ;
Kawaoka, Y ;
Kodihalli, S ;
Krauss, S ;
Markwell, D ;
Murti, KG ;
Norwood, M ;
Senne, D ;
Sims, L ;
Takada, A ;
Webster, RG .
VIROLOGY, 1998, 252 (02) :331-342
[10]   Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks [J].
Sturm-Ramirez, KM ;
Ellis, T ;
Bousfield, B ;
Bissett, L ;
Dyrting, K ;
Rehg, JE ;
Poon, L ;
Guan, Y ;
Peiris, M ;
Webster, RG .
JOURNAL OF VIROLOGY, 2004, 78 (09) :4892-4901