Design of sequence-specific DNA-binding ligands

被引:45
作者
Nielsen, PE
机构
[1] Center for Biomolecular Recognition, Dept. for Biochemistry and Genetics, Panum Institute, DK-2200 N Copenhagen
关键词
DNA recognition; triplexes; molecular recognition; peptide nucleic acids;
D O I
10.1002/chem.19970030404
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Double-stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequence-selectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence-specific DNA-binding ligands, such as triplex-forming oligonucleotides, peptide nucleic acids and minor groove binding polyamides.
引用
收藏
页码:505 / 508
页数:4
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