Threading your way to protein function

被引:6
作者
Firestine, SM
Nixon, AE
Benkovic, SJ
机构
来源
CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 10期
关键词
MANDELATE RACEMASE; CRYSTAL-STRUCTURE; ACTIVE-SITE; MECHANISM; SEQUENCE; IDENTIFICATION; SUPERFAMILY; PREDICTION; RESOLUTION; SEARCH;
D O I
10.1016/S1074-5521(96)90061-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.
引用
收藏
页码:779 / 783
页数:5
相关论文
共 23 条
[1]  
ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[2]   Biotin carboxylase comes into the fold [J].
Artymiuk, PJ ;
Poirrette, AR ;
Rice, DW ;
Willett, P .
NATURE STRUCTURAL BIOLOGY, 1996, 3 (02) :128-132
[3]   FUNCTIONALLY DIVERSE ENZYME SUPERFAMILY THAT ABSTRACTS THE ALPHA-PROTONS OF CARBOXYLIC-ACIDS [J].
BABBITT, PC ;
MRACHKO, GT ;
HASSON, MS ;
HUISMAN, GW ;
KOLTER, R ;
RINGE, D ;
PETSKO, GA ;
KENYON, GL ;
GERLT, JA .
SCIENCE, 1995, 267 (5201) :1159-1161
[4]  
Barth A, 1994, Drug Des Discov, V12, P89
[5]  
Barth A, 1993, Drug Des Discov, V10, P297
[6]   PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].
BERNSTEIN, FC ;
KOETZLE, TF ;
WILLIAMS, GJB ;
MEYER, EF ;
BRICE, MD ;
RODGERS, JR ;
KENNARD, O ;
SHIMANOUCHI, T ;
TASUMI, M .
JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542
[7]   ROLE OF A BURIED ACID GROUP IN MECHANISM OF ACTION OF CHYMOTRYPSIN [J].
BLOW, DM ;
BIRKTOFT, JJ ;
HARTLEY, BS .
NATURE, 1969, 221 (5178) :337-&
[8]   Protein sequence motifs [J].
Bork, P ;
Koonin, EV .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (03) :366-376
[9]   A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTER OF A TRIACYLGLYCEROL LIPASE [J].
BRADY, L ;
BRZOZOWSKI, AM ;
DEREWENDA, ZS ;
DODSON, E ;
DODSON, G ;
TOLLEY, S ;
TURKENBURG, JP ;
CHRISTIANSEN, L ;
HUGEJENSEN, B ;
NORSKOV, L ;
THIM, L ;
MENGE, U .
NATURE, 1990, 343 (6260) :767-770
[10]  
FISCHER D, 1994, PROTEIN SCI, V3, P769