Viral vectors: from virology to transgene expression

被引：250

作者：

Bouard, D.

Alazard-Dany, N.

Cosset, F-L ^{[1
]}

机构：

[1] ENS Lyon, INSERM, Human Virol Dept, U758, F-69007 Lyon, France

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2009年 / 157卷 / 02期

关键词：

viral vectors; gene therapy; AAV; Ad; HSV; lentivectors; pseudotyping; cell targeting; transcriptional targeting; vectors production; EFFICIENT GENE-TRANSFER; RECOMBINANT ADENOASSOCIATED VIRUS; ENGINEERED LENTIVIRAL VECTORS; DEPENDENT ADENOVIRAL VECTORS; TRANSDUCE AIRWAY EPITHELIA; SITE-SPECIFIC INTEGRATION; HSV-1 AMPLICON VECTORS; THYMIDINE KINASE GENE; RETROVIRAL VECTORS; IN-VIVO;

D O I：

10.1038/bjp.2008.349

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.

引用

收藏

页码：153 / 165

页数：13

相关论文

共 133 条

[1] Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning [J].

Aiuti, A ;

Slavin, S ;

Aker, M ;

Ficara, F ;

Deola, S ;

Mortellaro, A ;

Morecki, S ;

Andolfi, G ;

Tabucchi, A ;

Carlucci, F ;

Marinello, E ;

Cattaneo, F ;

Vai, S ;

Servida, P ;

Miniero, R ;

Roncarolo, MG ;

Bordignon, C .

SCIENCE, 2002, 296 (5577) :2410-2413

[2]

Andreas B, 1999, J HIGH ENERGY PHYS

[3] Computational redesign of endonuclease DNA binding and cleavage specificity [J].

Ashworth, Justin ;

Havranek, James J. ;

Duarte, Carlos M. ;

Sussman, Django ;

Monnat, Raymond J., Jr. ;

Stoddard, Barry L. ;

Baker, David .

NATURE, 2006, 441 (7093) :656-659

[4] Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors [J].

Baum, C ;

Kustikova, O ;

Modlich, U ;

Li, ZX ;

Fehse, B .

HUMAN GENE THERAPY, 2006, 17 (03) :253-263

[5]

Beck C, 2004, CURR GENE THER, V4, P457

[6] Improving rAAV production and purification: towards the definition of a scaleable process [J].

Blouin, V ;

Brument, N ;

Toublanc, E ;

Raimbaud, I ;

Moullier, P ;

Salvetti, A .

JOURNAL OF GENE MEDICINE, 2004, 6 :S223-S228

[7] An acidic cluster of the cytoplasmic tail of the RD114 virus glycoprotein controls assembly of retroviral envelopes [J].

Bouard, David ;

Sandrin, Virginie ;

Boson, Bertrand ;

Negre, Didier ;

Thomas, Gary ;

Granier, Christelle ;

Cosset, Francois-Loic .

TRAFFIC, 2007, 8 (07) :835-847

[8] VESICULAR STOMATITIS-VIRUS G GLYCOPROTEIN PSEUDOTYPED RETROVIRAL VECTORS - CONCENTRATION TO VERY HIGH-TITER AND EFFICIENT GENE-TRANSFER INTO MAMMALIAN AND NONMAMMALIAN CELLS [J].

BURNS, JC ;

FRIEDMANN, T ;

DRIEVER, W ;

BURRASCANO, M ;

YEE, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8033-8037

[9] Constructing the vertebrate genome: Evidence from eels that LINEs mobilize SINEs [J].

Bushman, F .

MOLECULAR CELL, 2002, 10 (05) :961-962

[10]

Bushman FD, 2002, CURR TOP MICROBIOL, V261, P165

← 1 2 3 4 5 6 7 8 9 10 →