Viral vectors: from virology to transgene expression

被引：250

作者：

Bouard, D.

Alazard-Dany, N.

Cosset, F-L ^{[1
]}

机构：

[1] ENS Lyon, INSERM, Human Virol Dept, U758, F-69007 Lyon, France

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2009年 / 157卷 / 02期

关键词：

viral vectors; gene therapy; AAV; Ad; HSV; lentivectors; pseudotyping; cell targeting; transcriptional targeting; vectors production; EFFICIENT GENE-TRANSFER; RECOMBINANT ADENOASSOCIATED VIRUS; ENGINEERED LENTIVIRAL VECTORS; DEPENDENT ADENOVIRAL VECTORS; TRANSDUCE AIRWAY EPITHELIA; SITE-SPECIFIC INTEGRATION; HSV-1 AMPLICON VECTORS; THYMIDINE KINASE GENE; RETROVIRAL VECTORS; IN-VIVO;

D O I：

10.1038/bjp.2008.349

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.

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收藏

页码：153 / 165

页数：13

相关论文

共 133 条

[71] Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration [J].

Montini, Eugenio ;

Cesana, Daniela ;

Schmidt, Manfred ;

Sanvito, Francesca ;

Ponzoni, Maurilio ;

Bartholomae, Cynthia ;

Sergi, Lucia Sergi ;

Benedicenti, Fabrizio ;

Ambrosi, Alessandro ;

Di Serio, Clelia ;

Doglioni, Claudio ;

von Kalle, Christof ;

Naldini, Luigi .

NATURE BIOTECHNOLOGY, 2006, 24 (06) :687-696

[72] Antibody-directed targeting of retroviral vectors via cell surface antigens [J].

Morizono, K ;

Bristol, G ;

Xie, YM ;

Kung, SKP ;

Chen, ISY .

JOURNAL OF VIROLOGY, 2001, 75 (17) :8016-8020

[73] Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo [J].

Nakai, H ;

Yant, SR ;

Storm, TA ;

Fuess, S ;

Meuse, L ;

Kay, MA .

JOURNAL OF VIROLOGY, 2001, 75 (15) :6969-6976

[74] In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector [J].

Naldini, L ;

Blomer, U ;

Gallay, P ;

Ory, D ;

Mulligan, R ;

Gage, FH ;

Verma, IM ;

Trono, D .

SCIENCE, 1996, 272 (5259) :263-267

[75] The influence of adenovirus fiber structure and function on vector development for gene therapy [J].

Nicklin, SA ;

Wu, E ;

Nemerow, GR ;

Baker, AH .

MOLECULAR THERAPY, 2005, 12 (03) :384-393

[76] Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: Safety of readministration [J].

Nunes, FA ;

Furth, EE ;

Wilson, JM ;

Raper, SE .

HUMAN GENE THERAPY, 1999, 10 (15) :2515-2526

[77] Meganucleases and DNA double-strand break-induced recombination:: Perspectives for gene therapy [J].

Paques, Frederic ;

Duchateau, Philippe .

CURRENT GENE THERAPY, 2007, 7 (01) :49-66

[78] A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal [J].

Parks, RJ ;

Chen, L ;

Anton, M ;

Sankar, U ;

Rudnicki, MA ;

Graham, FL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13565-13570

[79]

Peng K.W., 1998, Tumor Targeting, V3, P112

[80] Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors [J].

Peng, KW ;

Vile, RG ;

Cosset, FL ;

Russell, SJ .

GENE THERAPY, 1999, 6 (09) :1552-1557

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