Growth factor receptors in helminth parasites: Signalling and host-parasite relationships

被引：53

作者：

Dissous, Colette ^{[1
]}

Khayath, Naji ^{[1
]}

Vicogne, Jerome ^{[1
]}

Capron, Monique ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, U547, F-59019 Lille, France

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

parasite; helminth; receptor kinase; growth factor; signalling; host-parasite relationship;

D O I：

10.1016/j.febslet.2006.03.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2968 / 2975

页数：8

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