Human embryonic stem cells as a cellular model for human disorders

被引：30

作者：

Ben-Nun, Inbar Friedrich ^{[1
]}

Benvenisty, Nissim ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 252卷 / 1-2期

关键词：

human embryonic stem cells; genetic diseases; human disorders; nuclear transfer; preimplantation genetic diagnosis; genetic manipulation; gene trap;

D O I：

10.1016/j.mce.2006.03.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders: The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：154 / 159

页数：6

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