Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus

被引：52

作者：

Alarcón-Riquelme, ME ^{[1
]}

机构：

[1] Univ Uppsala, Rudbeck Lab, Dept Genet & Pathol, Uppsala, Sweden

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 04期

关键词：

autoimmunity; repression; runt-domain; susceptibility; transcription;

D O I：

10.1186/ar1203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune disease. A new pathway of disease pathogenesis opens new avenues of research with thousands of questions that remain to be answered. In this review I attempt to propose how the RUNX proteins might be involved in these diseases and review current knowledge on this very interesting trio of transcription factors that was previously only suspected to be involved in cancer.

引用

页码：169 / 173

页数：5

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