The synthesis of 8,8-disubstituted tricyclic analogs of artemisinin

被引：19

作者：

Haraldson, CA

Karle, JM

Freeman, SG

Duvadie, RK

Avery, MA

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,NATL CTR DEV NAT PROD,DEPT MED CHEM,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,DEPT CHEM,UNIVERSITY,MS 38677

[3] WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPT THERAPEUT,WASHINGTON,DC 20307

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(97)00432-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two tricyclic analogs of artemisinin were designed based on a Comparative Molecular Field Analysis (CoMFA) model, and synthesized for antimalarial testing as part of a program to construct and validate modeling tools for drug design of novel antimalarial agents based on the natural product lead, (+)-artemisinin. (C) 1997 Elsevier Science Ltd.

引用

页码：2357 / 2362

页数：6

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