CD4-independent infection by HIV-2 (ROD/B): Use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry

被引：132

作者：

Reeves, JD

McKnight, A

Potempa, S

Simmons, G

Gray, PW

Power, CA

Wells, T

Weiss, RA

Talbot, SJ

机构：

[1] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

[2] ICOS CORP,BOTHELL,WA 98021

[3] GLAXO WELLCOME RES & DEV SA,GENEVA BIOMED RES INST,CH-1228 PLAN LES OUATES,SWITZERLAND

来源：

VIROLOGY | 1997年 / 231卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/viro.1997.8508

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have assayed a variety of 7tm chemokine receptors (CCR-2b, CCR-3, CCR-4, CCR-5, CXCR-1, CXCR-4) and two orphan 7tm receptors (V28 and EBl.1) for their ability to allow infection of CD4-negative feline kidney CCC cells by the HIV-2 strains ROD/A and ROD/B. We found that ROD/B was able to use CXCR-4 transiently expressed in CCC cells, and infection by ROD/A was enhanced 15-fold in the presence of sCD4. Feline CCC cells also became permissive to ROD/B and ROD/A entry when transiently transfected with the chemokine receptor CCR-3 or the orphan 7tm receptor V28, when cultured in the presence of sCD4. Entry of ROD/A into CCC cells expressing CCR-3 could be blocked by 800 ng/ml eotaxin, the natural ligand for CCR-3. (C) 1997 Academic Press.

引用

收藏

页码：130 / 134

页数：5

相关论文

共 28 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2] A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains [J].

Berson, JF ;

Long, D ;

Doranz, BJ ;

Rucker, J ;

Jirik, FR ;

Doms, RW .

JOURNAL OF VIROLOGY, 1996, 70 (09) :6288-6295

[3] The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates [J].

Choe, H ;

Farzan, M ;

Sun, Y ;

Sullivan, N ;

Rollins, B ;

Ponath, PD ;

Wu, LJ ;

Mackay, CR ;

LaRosa, G ;

Newman, W ;

Gerard, N ;

Gerard, C ;

Sodroski, J .

CELL, 1996, 85 (07) :1135-1148

[4] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 INFECTION AND FUSION OF CD4-NEGATIVE HUMAN CELL-LINES - INDUCTION AND ENHANCEMENT BY SOLUBLE CD4 [J].

CLAPHAM, PR ;

MCKNIGHT, A ;

WEISS, RA .

JOURNAL OF VIROLOGY, 1992, 66 (06) :3531-3537

[5] ISOLATION OF A NEW HUMAN RETROVIRUS FROM WEST-AFRICAN PATIENTS WITH AIDS [J].

CLAVEL, F ;

GUETARD, D ;

BRUNVEZINET, F ;

CHAMARET, S ;

REY, MA ;

SANTOSFERREIRA, MO ;

LAURENT, AG ;

DAUGUET, C ;

KATLAMA, C ;

ROUZIOUX, C ;

KLATZMANN, D ;

CHAMPALIMAUD, JL ;

MONTAGNIER, L .

SCIENCE, 1986, 233 (4761) :343-346

[6]

COHEN J, 1995, SCIENCE, V270, P30, DOI 10.1126/science.270.5233.30a

[7]

CRANDELL RA, 1973, IN VITRO CELL DEV B, V9, P176, DOI 10.1007/BF02618435

[8] Identification of a major co-receptor for primary isolates of HIV-1 [J].

Deng, HK ;

Liu, R ;

Ellmeier, W ;

Choe, S ;

Unutmaz, D ;

Burkhart, M ;

DiMarzio, P ;

Marmon, S ;

Sutton, RE ;

Hill, CM ;

Davis, CB ;

Peiper, SC ;

Schall, TJ ;

Littman, DR ;

Landau, NR .

NATURE, 1996, 381 (6584) :661-666

[9] A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors [J].

Doranz, BJ ;

Rucker, J ;

Yi, YJ ;

Smyth, RJ ;

Samson, M ;

Peiper, SC ;

Parmentier, M ;

Collman, RG ;

Doms, RW .

CELL, 1996, 85 (07) :1149-1158

[10] HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 [J].

Dragic, T ;

Litwin, V ;

Allaway, GP ;

Martin, SR ;

Huang, YX ;

Nagashima, KA ;

Cayanan, C ;

Maddon, PJ ;

Koup, RA ;

Moore, JP ;

Paxton, WA .

NATURE, 1996, 381 (6584) :667-673