Nociceptin and its receptor in guinea-pig sympathetic ganglia

被引：18

作者：

Kummer, W

Fischer, A

机构：

[1] Inst. for Anatomy and Cell Biology, Justus-Liebig-Univ., Aulweg 123, D., Giessen

来源：

NEUROSCIENCE LETTERS | 1997年 / 234卷 / 01期

关键词：

nociceptin; orphanin FQ; opioid receptor-like receptor; sympathetic ganglion; paraganglionic cells; guinea pig;

D O I：

10.1016/S0304-3940(97)00662-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The occurrence and distribution of nociceptin, a 17-amino acid peptide with structural similarity to dynorphin A, and its receptor, opioid receptor-like-1 (ORL1) receptor, were investigated in the guinea-pig sympathetic nervous system by means of immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR), respectively. Immunofluorescence revealed varicose nociceptin-immunoreactive axons and some paraganglionic cells in prevertebral (coeliaco-superior mesenteric, inferior mesenteric), but not in paravertebral (superior cervical, stellate, lumbar chain) sympathetic ganglia. Messenger RNA for the ORL1 receptor, however, was detected by RT-PCR in both para-and prevertebral ganglia. The findings suggest participation of the nociceptin/ORL1 receptor signalling pathway in processing of information within prevertebral ganglia, and a general responsiveness of sympathetic neurons to nociceptin. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：35 / 38

页数：4

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