Brief Report: Functional Brown Adipose Tissue in Healthy Adults.

被引：2347

作者：

Virtanen, Kirsi A. ^{[2
]}

Lidell, Martin E. ^{[1
]}

Orava, Janne ^{[2
]}

Heglind, Mikael ^{[1
]}

Westergren, Rickard ^{[1
]}

Niemi, Tarja ^{[3
]}

Taittonen, Markku ^{[4
]}

Laine, Jukka ^{[5
]}

Savisto, Nina-Johanna ^{[2
]}

Enerback, Sven ^{[1
]}

Nuutila, Pirjo ^{[2
,6
]}

机构：

[1] Univ Gothenburg, Dept Med & Clin Genet, Inst Biomed, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden

[2] Univ Turku, Turku PET Ctr, Turku, Finland

[3] Turku Univ Hosp, Dept Surg, FIN-20520 Turku, Finland

[4] Turku Univ Hosp, Dept Anesthesiol, FIN-20520 Turku, Finland

[5] Turku Univ Hosp, Dept Pathol, FIN-20520 Turku, Finland

[6] Turku Univ Hosp, Dept Med, FIN-20520 Turku, Finland

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 15期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

ADAPTIVE THERMOGENESIS; THYROID-HORMONE; FAT; PHEOCHROMOCYTOMA; DIFFERENTIATION; TEMPERATURE; REDUCTION; GLUCOSE; HUMANS; MICE;

D O I：

10.1056/NEJMoa0808949

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.

引用

页码：1518 / 1525

页数：8

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