Neural mechanism of the antisecretory effect of peptide YY in the rat colon in vivo

被引：7

作者：

Chariot, J ^{[1
]}

Tsocas, A ^{[1
]}

Souli, A ^{[1
]}

Presset, O ^{[1
]}

Rozé, C ^{[1
]}

机构：

[1] Fac Med Xavier Bichat, INSERM, U410, F-75870 Paris 18, France

来源：

PEPTIDES | 2000年 / 21卷 / 01期

关键词：

peptide YY; jejunum; colon; rat; water transport; neural mechanisms;

D O I：

10.1016/S0196-9781(99)00174-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this work was to determine the mechanism of the antisecretory effect of peptide YY in the rat colon and whether this effect is physiological. In this prospect, doses of exogenous peptide YY producing physiological and supraphysiological plasma levels were intravenously infused in rats provided with colonic and jejunal ligated loops in vivo, under secretory stimulation by vasoactive intestinal peptide. Peptide YY decreased the secretory effect of VIP in a dose-related fashion. The effect of peptide YY was blocked or strongly decreased by tetrodotoxin, hexamethonium, idazoxan, haloperidol, and the cr antagonist BMY 14, 802 in both the colon and jejunum. We conclude that peptide YY decreases water and electrolyte secretion in the colonic mucosa by a complex neural mechanism involving at least two neurons connected through a nicotinic synapse, alpha-2 adrenoceptors and sigma receptors, and that this effect can occur with physiological doses of peptide YY. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：59 / 63

页数：5

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