Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

被引：536

作者：

Fiorucci, Stefano ^{[1
]}

Distrutti, Eleonora ^{[2
]}

机构：

[1] Univ Perugia, Sch Med, Dept Surg & Biomed Sci, Nuova Fac Med, I-06132 Perugia, Italy

[2] Azienda Osped Perugia, I-06132 Perugia, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2015年 / 21卷 / 11期

关键词：

GUT MICROBIOTA; NUCLEAR RECEPTOR; GASTRIC BYPASS; FXR; LIVER; LIGANDS; ALPHA; IDENTIFICATION; SECRETION; DISCOVERY;

D O I：

10.1016/j.molmed.2015.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The composition of the bile acid pool is a function of the microbial metabolism of bile acids in the intestine. Perturbations of the microbiota shape the bile acid pool and modulate the activity of bile acid-activated receptors (BARS) even beyond the gastrointestinal tract, triggering various metabolic axes and altering host metabolism. Bile acids, in turn, can also regulate the composition of the gut microbiome at the highest taxonomic levels. Primary bile acids from the host are preferential ligands for the farnesoid X receptor (FXR), while secondary bile acids from the microbiota are ligands for G-protein-coupled bile acid receptor 1 (GPBAR1). In this review, we examine the role of bile acid signaling in the regulation of intestinal microbiota and how changes in bile acid composition affect human metabolism. Bile acids may offer novel therapeutic modalities in inflammation, obesity, and diabetes.

引用

页码：702 / 714

页数：13

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