Dual stimuli-responsive supramolecular hydrogel of bionanoparticles and hyaluronan

被引：43

作者：

Chen, Limin ^{[1
]}

Zhao, Xia ^{[1
]}

Lin, Yuan ^{[1
]}

Su, Zhaohui ^{[1
]}

Wang, Qian ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

POLYMER CHEMISTRY | 2014年 / 5卷 / 23期

基金：

中国国家自然科学基金;

关键词：

VIRAL NANOPARTICLES; MOSAIC-VIRUS; PHOTODYNAMIC THERAPY; STEM-CELLS; OSTEOBLASTIC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; BACTERIOPHAGE M13; PROSTATE-CANCER; IN-VIVO; GROWTH;

D O I：

10.1039/c4py00819g

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

We report here the synthesis of a light- and chemical-responsive supramolecular hydrogel of bacteriophage M13 and hyaluronan locked by the molecular recognition between beta-cyclodextrin and trans-azobenzene moieties. Compared to rod-like tobacco mosaic virus (TMV), the filamentous bacteriophage M13 with higher aspect ratio and more flexible structure formed a much more robust hydrogel with hyaluronan, which was confirmed by the inversion test and rheological measurement. The resulting M13 hydrogel showed sol-gel transition behaviours induced by either photo-irradiation or competitive host or guest molecules. Moreover, cells could be facilely encapsulated and delivered using this supramolecular hydrogel with great cell viability.

引用

页码：6754 / 6760

页数：7

共 47 条

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