Comparative Evaluation of Two Methods for Studies of Experimental Focal Ischemia: Magnetic Resonance Tomography and Triphenyltetrazoleum Detection of Brain Injuries

被引：34

作者：

Silachev, D. N. ^{[1
]}

Uchevatkin, A. A. ^{[2
]}

Pirogov, Yu. A. ^{[2
]}

Zorov, D. B. ^{[1
]}

Isaev, N. K. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozyorsky Inst Physicochem Biol, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Training & Res Interfac Ctr Magnet Tomog & Spect, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

cerebral ischemia; magnetic resonance tomography; triphenyltetrazoleum chloride; CEREBRAL-ARTERY OCCLUSION; STROKE; RAT; MRI; ISRADIPINE; MODELS;

D O I：

10.1007/s10517-009-0489-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The volumes of foci of injuries, evaluated by T2-suspended MRT images and analysis of histological sections stained by triphenyltetrazoleum chloride, were compared on a model of unilateral intravascular blocking of the middle cerebral artery branch. The two methods for evaluation of foci of lesions gave close results, correlating with the severity of neurological deficiency in animals subjected to ischemia, manifesting in behavioral tests.

引用

页码：269 / 272

页数：4

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