Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

被引：273

作者：

Santra, Santimukul ^{[1
]}

Kaittanis, Charalambos ^{[1
]}

Grimm, Jan ^{[2
]}

Perez, J. Manuel ^{[1
]}

机构：

[1] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Nanosci Technol Ctr,Chem Dept, Orlando, FL 32826 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA

来源：

SMALL | 2009年 / 5卷 / 16期

关键词：

click chemistry; drug delivery; magnetic materials; magnetic resonance imaging; IN-VIVO; MAGNETIC NANOPARTICLES; CLICK CHEMISTRY; CELLS; DELIVERY; PROBE; VITRO;

D O I：

10.1002/smll.200900389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both. an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.

引用

页码：1862 / 1868

页数：7

共 28 条

[1] Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes [J].

Choi, Jong Hyun ;

Nguyen, Freddy T. ;

Barone, Paul W. ;

Heller, Daniel A. ;

Moll, Anthonie E. ;

Patel, Dhaval ;

Boppart, Stephen A. ;

Strano, Michael S. .

NANO LETTERS, 2007, 7 (04) :861-867

[2] Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications [J].

Gupta, AK ;

Gupta, M .

BIOMATERIALS, 2005, 26 (18) :3995-4021

[3] Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes [J].

Josephson, L ;

Kircher, MF ;

Mahmood, U ;

Tang, Y ;

Weissleder, R .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :554-560

[4] High-efficiency intracellular magnetic labeling with novel superparamagnetic-tat peptide conjugates [J].

Josephson, L ;

Tung, CH ;

Moore, A ;

Weissleder, R .

BIOCONJUGATE CHEMISTRY, 1999, 10 (02) :186-191

[5] Uptake and metabolism of a dual fluorochrome tat-nanoparticle in HeLa cells [J].

Koch, AM ;

Reynolds, F ;

Kircher, MF ;

Merkle, HP ;

Weissleder, R ;

Josephson, L .

BIOCONJUGATE CHEMISTRY, 2003, 14 (06) :1115-1121

[6]

Kolb HC, 2001, ANGEW CHEM INT EDIT, V40, P2004, DOI 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.3.CO

[7]

2-X

[8] Thermally cross-linked superparamagnetic iron oxide nanoparticles: Synthesis and application as a dual Imaging probe for cancer in vivo [J].

Lee, Haerim ;

Yu, Mi Kyung ;

Park, Sangjin ;

Moon, Sungmin ;

Min, Jung Jun ;

Jeong, Yong Yeon ;

Kang, Hae-Won ;

Jon, Sangyong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (42) :12739-12745

[9] Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging [J].

Lee, Haerim ;

Lee, Eunhye ;

Kim, Do Kyung ;

Jang, Nam Kyu ;

Jeong, Yong Yeon ;

Jon, Sangyong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (22) :7383-7389

[10] Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells [J].

Lewin, M ;

Carlesso, N ;

Tung, CH ;

Tang, XW ;

Cory, D ;

Scadden, DT ;

Weissleder, R .

NATURE BIOTECHNOLOGY, 2000, 18 (04) :410-414

← 1 2 3 →