Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

被引：273

作者：

Santra, Santimukul ^{[1
]}

Kaittanis, Charalambos ^{[1
]}

Grimm, Jan ^{[2
]}

Perez, J. Manuel ^{[1
]}

机构：

[1] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Nanosci Technol Ctr,Chem Dept, Orlando, FL 32826 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA

来源：

SMALL | 2009年 / 5卷 / 16期

关键词：

click chemistry; drug delivery; magnetic materials; magnetic resonance imaging; IN-VIVO; MAGNETIC NANOPARTICLES; CLICK CHEMISTRY; CELLS; DELIVERY; PROBE; VITRO;

D O I：

10.1002/smll.200900389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both. an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells.

引用

页码：1862 / 1868

页数：7

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