Shedding light onto live molecular targets

被引:1538
作者
Weissleder, Ralph [1 ]
Ntziachristos, Vasilis
机构
[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA USA
关键词
D O I
10.1038/nm0103-123
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.
引用
收藏
页码:123 / 128
页数:6
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