Shedding light onto live molecular targets

被引：1538

作者：

Weissleder, Ralph ^{[1
]}

Ntziachristos, Vasilis

机构：

[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 01期

关键词：

D O I：

10.1038/nm0103-123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

引用

页码：123 / 128

页数：6

共 88 条

[51] Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis [J].

Moore, A ;

Marecos, E ;

Simonova, M ;

Weissleder, R ;

Bogdanov, A .

MICROVASCULAR RESEARCH, 1998, 56 (03) :145-153

[52]

Moore Anna, 1998, Invasion and Metastasis, V18, P192, DOI 10.1159/000024512

[53] Antibodies labeled with fluorescence-agent excitable by infrared rays [J].

Muguruma, N ;

Ito, S ;

Hayashi, S ;

Taoka, S ;

Kakehashi, H ;

Ii, K ;

Shibamura, S ;

Takesako, K .

JOURNAL OF GASTROENTEROLOGY, 1998, 33 (04) :467-471

[54] Intrinsic fluorescence spectroscopy in turbid media:: disentangling effects of scattering and absorption [J].

Müller, MG ;

Georgakoudi, I ;

Zhang, QG ;

Wu, J ;

Feld, MS .

APPLIED OPTICS, 2001, 40 (25) :4633-4646

[55] Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform [J].

Neri, D ;

Carnemolla, B ;

Nissim, A ;

Leprini, A ;

Querzè, G ;

Balza, E ;

Pini, A ;

Tarli, L ;

Halin, C ;

Neri, P ;

Zardi, L ;

Winter, G .

NATURE BIOTECHNOLOGY, 1997, 15 (12) :1271-1275

[56] Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement [J].

Ntziachristos, V ;

Yodh, AG ;

Schnall, M ;

Chance, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2767-2772

[57] MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions [J].

Ntziachristos, V ;

Yodh, AG ;

Schnall, MD ;

Chance, B .

NEOPLASIA, 2002, 4 (04) :347-354

[58] Probing physiology and molecular function using optical imaging: applications to breast cancer [J].

Ntziachristos, V ;

Chance, B .

BREAST CANCER RESEARCH, 2001, 3 (01) :41-46

[59] Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media [J].

Ntziachristos, V ;

Weissleder, R .

MEDICAL PHYSICS, 2002, 29 (05) :803-809

[60]

Ntziachristos V., 2002, NAT MED, V8, P575

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