Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus

被引：65

作者：

Cui, Chuan-Ming ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Li, Chun-Shun ^{[1
]}

Sun, Hao-Fen ^{[1
]}

Gan, Shu-Shan ^{[1
,2
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2009年 / 92卷 / 07期

关键词：

NIGER EN-13; POLYSIPHONIA-URCEOLATA; RED ALGA; CIRCUMDATIN;

D O I：

10.1002/hlca.200900084

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC50 value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.

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页码：1366 / 1370

页数：5

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