Regional manifestations and control of the immune system

被引:89
作者
Saadi, S
Wrenshall, LE
Platt, JL [1 ]
机构
[1] Mayo Clin, Dept Surg, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Mol Biol & Biochem, Rochester, MN USA
[3] Univ Washington, Dept Surg, Seattle, WA 98195 USA
[4] Mayo Clin, Dept Immunol, Rochester, MN USA
[5] Mayo Clin, Dept Pediat, Rochester, MN USA
关键词
immunity; vascular endothelium; heparan sulfate proteoglycan; complement; antigen-presenting cells;
D O I
10.1096/fj.01-0690hyp
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although immune responses are generally considered to be systemic, local events such as interaction of complement products with blood vessels and with inflammatory cells play a pivotal role in determining the nature and manifestations of immune responses. This paper will discuss how blood vessel physiology and immunity influence one another to reach homeostasis upon exposure to an infectious agent. We review new insights into the mechanisms by which the microenvironment of tissues protects against microbial invasion yet facilitates migration of leukocytes and 'decides' whether immunity or tolerance ensues and whether, in the face of immunity, protective responses or tissue injury ensues. These 'decisions' are made based on interaction of components of normal tissues such as proteoglycans and injured tissues such as cell-associated cytokines with receptors on immune cells and blood vessels.
引用
收藏
页码:849 / 856
页数:8
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