Encapsulation and Sustained Release of Curcumin using Superparamagnetic Silica Reservoirs

被引：56

作者：

Chin, Suk Fun ^{[1
]}

Iyer, K. Swaminathan ^{[1
]}

Saunders, Martin ^{[2
]}

St Pierre, Tim G. ^{[3
]}

Buckley, Craig ^{[4
]}

Paskevicius, Mark ^{[4
]}

Raston, Colin L. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Ctr Strateg NanoFabricat, Crawley, WA 6009, Australia

[2] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia

[3] Univ Western Australia, Sch Phys, Ctr Strateg NanoFabricat, Crawley, WA 6009, Australia

[4] Curtin Univ Technol, Dept Imaging & Appl Phys, Perth, WA 6845, Australia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 23期

关键词：

curcumin; drug delivery; silica capsule; superparamagnetics; sustained release; ORDERED MESOPOROUS SILICA; CONTROLLED DRUG-DELIVERY; NANOPARTICLES; MAGNETITE;

D O I：

10.1002/chem.200802747

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The formation of magnetic nanocomposites of silica with curcumin in the cetyltrimethylammonium bromide (CTAB) micellar rod in the presence of super-paramagnetic Fe3O4 nanoparticles was demonstrated. It was observed that the high loading of Fe3O4 nanoparticles in the silica carriers might impart high magnetophoretic mobility for targeted delivery. These magnetic carriers provided an alternative method for site-specific delivery of curcumin with the ability to concentrate them on desired cells or organs by an external magnetic field and increase their residence time in the vicinity of the target area. Small-angle X-ray scattering patterns for the samples before magnetic separation exhibited a distinctive Bragg peak corresponding to ordered porous nonmagnetic silica structures. This study provided a simple and strategic route to encapsulate curcumin inside superparamagnetic porous silica particles.

引用

页码：5661 / 5665

页数：5

共 37 条

[1]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[2]

One-pot synthesis of well ordered mesoporous magnetic carriers [J].