Changes in the B-cell repertoire with age

被引：149

作者：

Weksler, ME ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Div Geriatr & Gerontol, New York, NY 10021 USA

来源：

VACCINE | 2000年 / 18卷 / 16期

关键词：

aging; immunology; repertoire;

D O I：

10.1016/S0264-410X(99)00497-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Changes in the B-cell repertoire during aging include a shift in antibody specificities from foreign to autologous antigens associated with a decline in the activity of conventional B2. compared to B1 lymphocytes. The age-associated increase in B1 lymphocyte number and activity contribute to the increased serum concentration of autoantibodies and the B-cell clonal expansions that develop with age. Aging is also associated with a decreased diversity of the antibody response reflected in the preferential loss of IgG and high affinity antibodies following immunization with a foreign antigen. Many of these changes can be traced to an impaired capacity of T cells to support isotype switching and somatic mutation in the periphery and the generation of a diverse B-cell repertoire from bone marrow B-cell precursors, (C) 2000 Elsevier Science Ltd. AII rights reserved.

引用

页码：1624 / 1628

页数：5

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