Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods

被引：78

作者：

Roling, EE

Klepser, ME ^{[1
]}

Wasson, A

Lewis, RE

Ernst, EJ

Pfaller, MA

机构：

[1] Ferris State Univ, Coll Pharm, Big Rapids, MI 49307 USA

[2] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA

[3] Borgess Med Ctr, Kalamazoo, MI 49001 USA

[4] Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2002年 / 43卷 / 01期

关键词：

D O I：

10.1016/S0732-8893(02)00361-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activities of the echinocandins caspofungin and anidulafungin were evaluated alone and in combination With fluconazole using time-kill methods against isolates of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Cryptococcus neoformans. Antifungal concentrations tested against each isolate were 0.5 mug/mL and 20 mug/mL of fluconazole and 0.007 mug/mL and 2 mug/mL of both caspofungin and anidulafungin. In addition, 20 mug/mL of fluconazole was tested with 2 mug/mL of caspofungin and anidulafungin to test for additive or antagonistic activity. Finally 0.5 mug/mL of fluconazole was tested with 0.007 mug/mL of caspofungin and anidulafungin to test for synergy. Combinations of fluconazole and caspofungin or anidulafungin resulted in indifference. Azoleechinocandin combinations do not produce antagonistic effects; therefore, combinations of these agents may warrant future clinical evaluation. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：13 / 17

页数：5

共 13 条

[1] SECULAR TRENDS IN NOSOCOMIAL PRIMARY BLOOD-STREAM INFECTIONS IN THE UNITED-STATES, 1980-1989 [J].