Molecular Characterization of Human Plasmacytoid Dendritic Cells

被引:29
作者
Cao, Wei [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Unit 901, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
Plasmacytoid dendritic cells; type I interferon production; regulation of interferon responses; pDC development; CD4(+)CD56(+) hematodermic neoplasm; TOLL-LIKE RECEPTORS; INTERFERON-PRODUCING CELLS; SINGLE-STRANDED RNA; LOOP-HELIX PROTEINS; FACTOR SPI-B; SUBTRACTIVE HYBRIDIZATION; ANTIVIRAL RESPONSES; BACTERIAL-DNA; FACTOR E2-2; IFN-ALPHA;
D O I
10.1007/s10875-009-9284-x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Plasmacytoid dendritic cells (pDCs) represent a unique and important immune cell population capable of producing large quantifies of type I interferon (IFN) in response to viruses as well as nucleic acid-containing complexes from the host. These rare and mysterious cells have been revealed by in-depth molecular characterization. Several innate sensors and signaling molecules enriched in pDCs allow their specialized innate immune functions. In addition, human pDCs use a group of surface receptors that, through activation of a B-cell receptor (BCR)-like signaling pathway, modulate type I IFN responses. It is clear now that pDC development is influenced by distinctive transcription factors that specify a unique lineage. CD4(+)CD56(+) hematodermic neoplasm of human pDC origin has been revealed in explicit molecular terms. A detailed molecular description of pDCs helps us better define, understand, and track human pDCs in relation to their functions and physiological involvement.
引用
收藏
页码:257 / 264
页数:8
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