Short report: Absence of protective neutralizng antibodies to West Nile virus in subjects following vaccination with Japanese encephalitis or dengue vaccines

被引：43

作者：

Kanesa-Thasan, N

Putnak, JR

Mangiafico, JA

Saluzzo, JF

Ludwig, GV

机构：

[1] USA, Inst Infect Dis, Frederick, MD 21702 USA

[2] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA

[3] Aventis Pasteur, Marcy Letoile, France

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2002年 / 66卷 / 02期

关键词：

D O I：

10.4269/ajtmh.2002.66.115

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Protection of individuals against West Nile (WN) encephalitis is an emerging concern in the United States and Europe. We investigated whether immunization with licensed inactivated Japanese encephalitis (JE) vaccine or experimental live attenuated dengue vaccines resulted in induction of cross-neutralizing antibodies against WN virus. Protective neutralizing antibody titers to WN virus were not detected in any volunteer despite successful immunization to related flaviviruses. Vaccination against JE or dengue is unlikely to prevent WN virus infection but may still protect against disease.

引用

页码：115 / 116

页数：2

共 15 条

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