Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease

被引：75

作者：

Monteleone, Giovanni ^{[1
]}

Pallone, Francesco ^{[1
]}

Macdonald, Thomas T. ^{[2
]}

机构：

[1] Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy

[2] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 02期

关键词：

IL-21; IL-21R; Cytokines; IBD; Common-gamma chain; INFLAMMATORY-BOWEL-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; CYTOKINE PRODUCTION; EPITHELIAL-CELLS; GUT INFLAMMATION; T(H)17 CELLS; TH17; CELLS; NOD MOUSE; IL-21;

D O I：

10.1016/j.cytogfr.2009.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-21 (IL-21) is produced mostly by activated CD4+ T cells and controls the differentiation and functional activity of effector T helper cells, counteracts the suppressive effects of regulatory T cells, and stimulates non-immune cells to make inflammatory mediators. IL-21-driven tissue damage has been demonstrated in a number of organs, such as the gut, pancreas, and brain. Therefore new treatment modalities to neutralise IL-21 in vivo would be a valuable addition to the therapeutic armamentarium to combat immune-mediated inflammation. Here we describe the emerging role of IL-21 in the initiation and progress of the tissue-damaging inflammatory response in immune-mediated pathologies. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：185 / 191

页数：7

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