E-NTPase/NTPDase: potential role as a regulatory element in inflammation

被引：13

作者：

Kannan, S ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

MEDICAL HYPOTHESES | 2002年 / 58卷 / 06期

关键词：

D O I：

10.1054/mehy.2001.1509

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammation is a process culminated by cellular components and soluble mediators act in concert to evolve a sustainable process to impart distress in vascularized tissue. Among the contributors, extracellular nucleotides are prominent in PMN granule release (degranulation); chemotaxis, enhanced expression of adhesion molecule on the surface of PMN. However, co-stimulatory effectors such as chemokines are required for the extracellular nucleotide-induced maximal effect in inflammation. Enzymes, which degrade the extracellular nucleotide(s), could potentially attenuate or minimize the extracellular nucleotide(s) induced effect by degradation. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：527 / 528

页数：2