Given a Cartesian product G = G(1) x ... x G(M) (m greater than or equal to 2) of nontrivial connected graphs G(i) and the base d, dimension D de Bruijn graph B(d, D), it is investigated under which conditions G is (or is not) a subgraph of B(d,D). We present a complete solution of this problem for the case D greater than or equal to 4. For D = 3, we give partial results including a complete solution for the case that G is a torus, i.e., G is the Cartesian product of cycles.