Fetal liver hematopoietic stem cell niches associate with portal vessels

被引：202

作者：

Khan, Jalal A. ^{[1
,2
,5
]}

Mendelson, Avital ^{[1
,2
]}

Kunisaki, Yuya ^{[1
,2
]}

Birbrair, Alexander ^{[1
,2
]}

Kou, Yan ^{[6
]}

Arnal-Estape, Anna ^{[1
,2
]}

Pinho, Sandra ^{[1
,2
]}

Ciero, Paul ^{[1
]}

Nakahara, Fumio ^{[1
,2
]}

Ma'ayan, Avi ^{[6
]}

Bergman, Aviv ^{[4
]}

Merad, Miriam ^{[5
]}

Frenette, Paul S. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[4] Albert Einstein Coll Med, Dept Syst & Computat Biol, Bronx, NY 10467 USA

[5] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

来源：

SCIENCE | 2016年 / 351卷 / 6269期

基金：

美国国家卫生研究院;

关键词：

SELF-RENEWAL; PROGENITORS; HOMEOSTASIS; QUIESCENCE;

D O I：

10.1126/science.aad0084

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow has been characterized, the nature of the fetal liver niche is not yet elucidated. We show that Nestin(+)NG2(+) pericytes associate with portal vessels, forming a niche promoting HSC expansion. Nestin(+)NG2(+) cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. After closure of the umbilical inlet at birth, portal vessels undergo a transition from Neuropilin-1(+)Ephrin-B2(+) artery to EphB4(+) vein phenotype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs away from portal vessels. These data support a model in which HSCs are titrated against a periportal vascular niche with a fractal-like organization enabled by placental circulation.

引用

页码：176 / 180

页数：5

共 27 条

[1]

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium [J].

Boisset, Jean-Charles ;

van Cappellen, Wiggert ;

Andrieu-Soler, Charlotte ;

Galjart, Niels ;

Dzierzak, Elaine ;

Robin, Catherine .

NATURE, 2010, 464 (7285) :116-U131

[2]

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells [J].

Bowie, Michelle B. ;

Kent, David G. ;

Copley, Michael R. ;

Eaves, Connie J. .

BLOOD, 2007, 109 (11) :5043-5048

[3]

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion [J].

Bruns, Ingmar ;

Lucas, Daniel ;

Pinho, Sandra ;

Ahmed, Jalal ;

Lambert, Michele P. ;

Kunisaki, Yuya ;

Scheiermann, Christoph ;

Schiff, Lauren ;

Poncz, Mortimer ;

Bergman, Aviv ;

Frenette, Paul S. .

NATURE MEDICINE, 2014, 20 (11) :1315-1320

[4]

Enrichr: interactive and collaborative HTML']HTML5 gene list enrichment analysis tool [J].

Chen, Edward Y. ;

Tan, Christopher M. ;

Kou, Yan ;

Duan, Qiaonan ;

Wang, Zichen ;

Meirelles, Gabriela Vaz ;

Clark, Neil R. ;

Ma'ayan, Avi .

BMC BIOINFORMATICS, 2013, 14

[5]

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells [J].

Chou, Song ;

Lodish, Harvey F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (17) :7799-7804

[6]

Circulation and chemotaxis of fetal hematopoietic stem cells [J].

Christensen, JL ;

Wright, DE ;

Wagers, AJ ;

Weissman, IL .

PLOS BIOLOGY, 2004, 2 (03) :368-377

[7]

Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo [J].

de Bruijn, MFTR ;

Speck, NA ;

Peeters, MCE ;

Dzierzak, E .

EMBO JOURNAL, 2000, 19 (11) :2465-2474

[8]

Endothelial and perivascular cells maintain haematopoietic stem cells [J].

Ding, Lei ;

Saunders, Thomas L. ;

Enikolopov, Grigori ;

Morrison, Sean J. .

NATURE, 2012, 481 (7382) :457-U65

[9]

Expansion of hematopoietic stem cells in the developing liver of a mouse embryo [J].

Ema, H ;

Nakauchi, H .

BLOOD, 2000, 95 (07) :2284-2288

[10]

The placenta is a niche for hematopoietic stem cells [J].

Gekas, C ;

Dieterlen-Lièvre, F ;

Orkin, SH ;

Mikkola, HKA .

DEVELOPMENTAL CELL, 2005, 8 (03) :365-375

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