Synthesis of 3-methyl-substituted pyrazolotriazolopyrimidin-4-one and pyrazolothiazolopyrimidin-4-one derivatives

被引：12

作者：

Guccione, S ^{[1
]}

Scolaro, LM ^{[1
]}

Russo, F ^{[1
]}

机构：

[1] UNIV MESSINA,DIPARTIMENTO CHIM INORGAN ANAL & STRUTTURA MOLEC,SEZIONE MESSINA,I-98166 MESSINA,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 02期

关键词：

D O I：

10.1002/jhet.5570330239

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a part of a research on anti-inflammatory analgesic compounds 3-methyl substituted pyrazolotriazolopyrimidin-4-one and pyrazolothiazolopyrimidin-4-one derivatives were prepared by previously reported procedures. None of the compounds showed improved activity when compared with the previously reported unsubstituted analogs.

引用

收藏

页码：459 / 463

页数：5

相关论文

共 19 条

[1]

ACKERMAN NR, PROGR INFLAMMATION R, V35

[2] REACTIONS OF ALPHA-CYANO-BETA-METHOXY-BETA-ALKYLACRYLIC ESTERS WITH HYDRAZINE AND HYDROXYLAMINE [J].

BABA, H ;

HORI, I ;

HAYASHI, T ;

MIDORIKA.H .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1969, 42 (06) :1653-+

[3] UBER THIAZOLE .29. UBER DIE KONDENSATIONSPRODUKTE VON THIOSEMICARBAZID MIT ALPHA-CHLORACETESSIGESTER UND EINE NEUARTIGE RINGVERENGUNG DES 2-AMINO-5-METHYL-6-CARBATHOXY-1.3.4-THIODIAZINS ZUM 3-METHYL-4-CARBATHOXY-5-AMINOPYRAZOL [J].

BEYER, H ;

WOLTER, G .

CHEMISCHE BERICHTE-RECUEIL, 1956, 89 (07) :1652-1658

[4]

DOUGLASS IB, 1934, AM SOCIOL, V56, P1408

[5] NEW PYRAZOL DERIVATIVES .4. PREPARATION AND CYCLIZATION OF SOME ACCEPTOR-SUBSTITUTED N-(PYRAZOL-3-YL)THIOUREAS [J].

EISENACHER, T ;

PECH, R ;

BOHM, R .

JOURNAL FUR PRAKTISCHE CHEMIE, 1991, 333 (03) :437-446

[6]

ERREDE LA, 1977, J ORG CHEM, V42, P1

[7]

FRANK RL, 1948, ORG SYNTH, V28, P89

[8]

FUSCO R, 1967, HETEROCYCL COMPOUNDS, V20, P4

[9] UNFORESEEN ALKYLATING EFFECT OF TRIETHYLORTHOFORMATE IN THE SYNTHESIS OF PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES [J].

GUCCIONE, S ;

RAFFAELLI, A ;

BARRETTA, GU ;

SCOLARO, LM ;

PUCCI, S ;

RUSSO, F .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1995, 30 (04) :333-337

[10] Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo[3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one [J].

Guccione, S ;

Modica, M ;

Longmore, J ;

Shaw, D ;

Barretta, GU ;

Santagati, A ;

Santagati, M ;

Russo, F .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (01) :59-64