Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: A Swedish prospective case-control study

被引：37

作者：

Brendle, Annika ^{[1
]}

Brandt, Andreas ^{[1
]}

Johansson, Robert ^{[2
]}

Enquist, Kerstin ^{[3
]}

Hallmans, Goran ^{[3
]}

Hemminki, Kari ^{[1
,4
]}

Lenner, Per ^{[2
]}

Forsti, Asta ^{[1
,4
]}

机构：

[1] German Canc Res Ctr, Div Mol Genet Epidemiol C050, D-69120 Heidelberg, Germany

[2] Norrlands Univ Hosp, Dept Oncol, Umea, Sweden

[3] Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, S-90187 Umea, Sweden

[4] Karolinska Inst, Ctr Family & Community Med, Huddinge, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 03期

关键词：

Breast cancer; Chromosomal instability; Prognosis; Single nucleotide polymorphism; Susceptibility; MITOTIC CHECKPOINT GENES; CENP-F; ANEUPLOIDY; MITOSIN; SUSCEPTIBILITY; ASSOCIATION; SEGREGATION; MECHANISMS; EXPRESSION; PROGNOSIS;

D O I：

10.1016/j.ejca.2008.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal instability (CIN) is a major characteristic of many cancers. We investigated whether putatively functional single nucleotide polymorphisms (SNPs) in genes related to CIN (CENPF, ESPL1, NEK2, PTTG1, ZWILCH, ZWINT) affect breast cancer (BC) risk and clinical outcome in a Swedish cohort of 749 incident BC cases with detailed clinical data and up to 15 years of follow-up and 1493 matched controls. As a main observation, carriers of the A allele of the CENPF SNP rs438034 had a worse BC-specific survival compared to the wild type genotype GG carriers (hazard ratio (HR) 2.65, 95% confidence interval (CI) 1.19-5.90), although they were less likely to have regional lymph node metastases (odds ratio (OR) 0.71., 95% CI 0.51-1.01) and tumours; of stage II-IV (OR 0.73, 95% CI 0.54-0.99). As there is increasing evidence that CENPF is associated with poor prognosis in patients with primary BC, further independent studies are needed to clarify the importance of genetic variation in the CENPF gene in the clinic. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：435 / 442

页数：8

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