Effect of renal denervation on dynamic autoregulation of renal blood flow

被引:52
作者
DiBona, GF
Sawin, LL
机构
[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
[2] Univ Iowa, Carver Coll Med, Dept Physiol & Biophys, Iowa City, IA 52242 USA
[3] Vet Adm Med Ctr, Iowa City, IA 52242 USA
关键词
autoregulation; renal sympathetic nerve activity; transfer function analysis;
D O I
10.1152/ajprenal.00010.2004
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Vasoconstrictor intensities of renal sympathetic nerve stimulation elevate the renal arterial pressure threshold for steady-state stepwise autoregulation of renal blood flow. This study examined the tonic effect of basal renal sympathetic nerve activity on dynamic autoregulation of renal blood flow in rats with normal (Sprague-Dawley and Wistar-Kyoto) and increased levels of renal sympathetic nerve activity (congestive heart failure and spontaneously hypertensive rats). Steady-state values of arterial pressure and renal blood flow before and after acute renal denervation were subjected to transfer function analysis. Renal denervation increased basal renal blood flow in congestive heart failure (+35 +/- 3%) and spontaneously hypertensive rats (+21 +/- 3%) but not in Sprague-Dawley and Wistar-Kyoto rats. Renal denervation significantly decreased transfer function gain (i.e., improved autoregulation of renal blood flow) and increased coherence only in spontaneously hypertensive rats. Thus vasoconstrictor intensities of renal sympathetic nerve activity impaired the dynamic autoregulatory adjustments of the renal vasculature to oscillations in arterial pressure. Renal denervation increased renal blood flow variability in spontaneously hypertensive rats and congestive heart failure rats. The contribution of vasoconstrictor intensities of basal renal sympathetic nerve activity to limiting renal blood flow variability may be important in the stabilization of glomerular filtration rate.
引用
收藏
页码:F1209 / F1218
页数:10
相关论文
共 20 条
[1]   Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats [J].
Abu-Amarah, I ;
Ajikobi, DO ;
Bachelard, H ;
Cupples, WA ;
Salevsky, FC .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (05) :R1543-R1552
[2]   Long-term control of renal blood flow: what is the role of the renal nerves? [J].
Barrett, CJ ;
Navakatikyan, MA ;
Malpas, SC .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (05) :R1534-R1545
[3]  
Berger CS, 1998, J EXP BIOL, V201, P3425
[4]   NEURAL CONTROL OF RENAL-FUNCTION IN EDEMA-FORMING STATES [J].
DIBONA, GF ;
HERMAN, PJ ;
SAWIN, LL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (06) :R1017-R1024
[5]   Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure [J].
DiBona, GF ;
Sawin, LL .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (05) :H1857-H1863
[6]   Frequency response of the renal vasculature in congestive heart failure [J].
DiBona, GF ;
Sawin, LL .
CIRCULATION, 2003, 107 (16) :2159-2164
[7]   Neural control of renal function [J].
DiBona, GF ;
Kopp, UC .
PHYSIOLOGICAL REVIEWS, 1997, 77 (01) :75-197
[8]  
DIBONA GF, 1988, JUXTAGLOMERULAR APPA
[9]  
FOLKOW B, 1982, PHYSIOL REV, V62, P345
[10]   Autoregulation of renal blood flow in the conscious dog and the contribution of the tubuloglomerular feedback [J].
Just, A ;
Wittmann, U ;
Ehmke, H ;
Kirchheim, HR .
JOURNAL OF PHYSIOLOGY-LONDON, 1998, 506 (01) :275-290