Regulating the thermal response of PNIPAM hydrogels by controlling the adsorption of magnetite nanoparticles

被引：25

作者：

Dionigi, Chiara ^{[1
]}

Pineiro, Yolanda ^{[2
]}

Riminucci, Alberto ^{[1
]}

Banobre, Manuel ^{[2
]}

Rivas, Jose ^{[2
]}

Dediu, Valentin ^{[1
]}

机构：

[1] CNR ISMN Bologna, I-40129 Bologna, Italy

[2] Univ Santiago de Compostela, Dept Fis Aplicada, Santiago De Compostela 15706, Spain

来源：

APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | 2014年 / 114卷 / 02期

关键词：

POLY(N-ISOPROPYLACRYLAMIDE) MICROSPHERES; DRUG; CHEMOTHERAPY; PARAMETERS; MICROGELS; DELIVERY; DESIGN; FIELD;

D O I：

10.1007/s00339-013-7620-8

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Thermoswitchable magnetic hydrogels are being extensively investigated because of their great potential for medical applications. Indeed, they can behave as smart carriers able to transport drugs to a chosen part of the body and release them via magneto-thermal activation by an external alternating magnetic field. We report on the magnetization of the thermosensitive poly(N-isopropylacrylamide) hydrogel through the adsorption of controlled amounts of magnetite nanoparticles. We show that the temperature at which the hydrogel contraction occurs (i.e. the lower critical solution temperature) can be controlled from 32 C-a similar to to 52 C-a similar to by varying the concentration of adsorbed nanoparticles. This is clearly shown by photon correlation spectroscopy. The results are an advance in the use of the magnetized poly(N-isopropylacrylamide) hydrogel as a flexible and adjustable nanomaterial and are of great interest in numerous applications which require drug release on demand.

引用

页码：585 / 590

页数：6

共 29 条

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EFFECT OF TEMPERATURE ON THE RELEASE RATE OF BIOMOLECULES FROM THERMALLY REVERSIBLE HYDROGELS [J].