Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications

被引：86

作者：

Xu, Chenjie ^{[1
]}

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

DALTON TRANSACTIONS | 2009年 / 29期

关键词：

IRON-OXIDE NANOPARTICLES; MONODISPERSE MAGNETIC NANOPARTICLES; SIZE-CONTROLLED SYNTHESIS; EPIDERMAL-GROWTH-FACTOR; HUMAN CANCER-CELLS; BIOMEDICAL APPLICATIONS; CHEMICAL-SYNTHESIS; DRUG-DELIVERY; PARTICLE-SIZE; FE3O4; NANOPARTICLES;

D O I：

10.1039/b900272n

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Superparamagnetic nanoparticles (NPs) have been attractive for medical diagnostics and therapeutics due to their unique magnetic properties and their ability to interact with various biomolecules of interest. The solution phase based chemical synthesis provides a near precise control on NP size, and monodisperse magnetic NPs with standard deviation in diameter of less than 10% are now routinely available. Upon controlled surface functionalization and coupling with fragments of DNA strands, proteins, peptides or antibodies, these NPs can be well-dispersed in biological solutions and used for drug delivery, magnetic separation, magnetic resonance imaging contrast enhancement and magnetic fluid hyperthermia. This Perspective reviews the common syntheses and controlled surface functionalization of monodisperse Fe3O4-based superparamagnetic NPs. It further outlines the exciting application potentials of these NPs in magnetic resonance imaging and drug delivery.

引用

页码：5583 / 5591

页数：9

共 81 条

[11] In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles:: Effect of MePEG molecular weight and particle size [J].