Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors

被引：89

作者：

Mieda, M

Yanagisawa, M

机构：

[1] Univ Texas, SW Med Ctr Dallas, Howard Hughes Med Inst, Dept Mol Genet, Dallas, TX 75390 USA

[2] Japan Sci & Tecnol Corp, Yanagisawa Orphan Receptor Project, Exploratory Res Adv Technol, Tokyo 1350064, Japan

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(02)00331-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

引用

页码：339 / 345

页数：7

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