Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women

被引:116
作者
Segraves, RT
Clayton, A
Croft, H
Wolf, A
Warnock, J
机构
[1] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44109 USA
[2] MetroHlth Med Syst, Cleveland, OH USA
[3] Univ Virginia, Dept Psychiat, Charlottesville, VA USA
[4] Univ Oklahoma, Dept Psychiat, Oklahoma City, OK USA
关键词
D O I
10.1097/01.jcp.0000125686.20338.c1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Premenopausal women meeting operational criteria for idiopathic, acquired, global hypoactive sexual desire disorder were studied in a randomized, double-blind, placebo-controlled, multiple-site escalating dose 112-day trial of bupropion sustained release. Outcome was measured by investigator-rating and self-administered questionnaires. All measures indicated greater sexual responsiveness in women receiving bupropion. The Changes in Sexual Functioning Questionnaire indicated that bupropion had significant effects on increasing measures of sexual arousal, orgasm completion, and sexual satisfaction.
引用
收藏
页码:339 / 342
页数:4
相关论文
共 19 条
[1]  
Balon R, 2003, SEXUAL PHARM FAST FA
[2]   Female sexual response: The role of drugs in the management of sexual dysfunction [J].
Basson, R .
OBSTETRICS AND GYNECOLOGY, 2001, 98 (02) :350-353
[3]   Prevalence of sexual dysfunction among newer antidepressants [J].
Clayton, AH ;
Pradko, JF ;
Croft, HA ;
Montano, CB ;
Leadbetter, RA ;
Bolden-Watson, C ;
Bass, KI ;
Donahue, RMJ ;
Jamerson, BD ;
Metz, A .
JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (04) :357-366
[4]  
Clayton AH, 1997, PSYCHOPHARMACOL BULL, V33, P747
[5]  
CRENSHAW TL, 1987, J SEX MARITAL THER, V13, P239
[6]   A placebo controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline [J].
Croft, H ;
Settle, E ;
Houser, T ;
Batey, SR ;
Donahue, RMJ ;
Ascher, JA .
CLINICAL THERAPEUTICS, 1999, 21 (04) :643-658
[7]   Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women [J].
Hackbert, L ;
Heiman, JR .
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE, 2002, 11 (02) :155-162
[8]   Neurochemical aspects of the sexual response cycle [J].
Halaris, A .
CNS SPECTRUMS, 2003, 8 (03) :211-216
[9]   Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: A preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects [J].
Kennedy, SH ;
McCann, SM ;
Masellis, M ;
McIntyre, RS ;
Raskin, J ;
McKay, G ;
Baker, GB .
JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (03) :181-186
[10]   Sexual dysfunction in the United States - Prevalence and predictors [J].
Laumann, EO ;
Paik, A ;
Rosen, RC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (06) :537-544