Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder

被引：57

作者：

Kalmar, Jessica H. ^{[1
,2
]}

Wang, Fei ^{[2
]}

Spencer, Linda ^{[2
]}

Edmiston, Erin ^{[2
]}

Lacadie, Cheryl M. ^{[3
]}

Martin, Andres ^{[4
]}

Constable, R. Todd ^{[3
,5
,6
]}

Duncan, James S. ^{[3
,5
,7
]}

Staib, Lawrence H. ^{[3
,5
,7
]}

Papademetris, Xenophon ^{[3
,5
]}

Blumberg, Hilary P. ^{[2
,3
,4
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, Mood Disorders Res Program, New Haven, CT 06511 USA

[2] Vet Affairs Connecticut Healthcare Syst, Dept Psychiat, West Haven, CT USA

[3] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA

[4] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06511 USA

[5] Yale Univ, Sch Med, Dept Biomed Engn, New Haven, CT 06511 USA

[6] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06511 USA

[7] Yale Univ, Sch Med, Dept Elect Engn, New Haven, CT 06511 USA

来源：

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | 2009年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Adolescents; Bipolar disorder; Magnetic resonance imaging; Prefrontal cortex; Development; Longitudinal; VOXEL-BASED MORPHOMETRY; GRAY-MATTER LOSS; NEURAL CIRCUITRY; CORTICAL DEVELOPMENT; BRAIN-DEVELOPMENT; FUNCTIONAL MRI; CORTEX; SCHIZOPHRENIA; CHILDREN; DYSFUNCTION;

D O I：

10.1017/S1355617709090584

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive Volume abnormalities during adolescence in bipolar disorder (1313). In the present study, a within-subject, longitudinal design was implemented to examine brain Volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BID I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater Volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostra] anterior cingulate cortex (p<.05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD. (JINS, 2009, 15, 476-481.)

引用

页码：476 / 481

页数：6

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