Mesenchymal stem cellular adhesion and cytotoxicity study of random biopolyester scaffolds for tissue engineering

被引：14

作者：

Tang, X. J. ^{[1
]}

Wu, Q. Y.

机构：

[1] Chinese Acad Med Sci, Dept Cardiac Surg, Cardiovasc Inst, Beijing 100037, Peoples R China

[2] Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100037, Peoples R China

[3] PUMC, Beijing 100037, Peoples R China

[4] First Hosp Tsinghua Univ, Dept Cardiovasc, Beijing 100016, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2006年 / 17卷 / 07期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1007/s10856-006-9225-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Mesenchymal stem cells (MSCs) were isolated from the bone marrow of rabbits and inoculated respectively on 3D scaffolds of poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) (PHBV), poly(butylenes succinate) (PBS) and different blends (100/0, 80/20, 50/50, 20/80, 0/100) (Wt%) in vitro. It was found that the (50/50) blends possessed the best performance on adhesion and cytotoxicity of MSCs. The scanning electronic microscopy (SEM) results showed that the (50/50) blends had the appropriate roughness for MSCs to attach and grow, which may be used as a suitable biomaterial to create small caliber vascular grafts.

引用

页码：627 / 632

页数：6

共 21 条

[1]

ARNALDO R, 2002, ARTIF ORGANS, V28, P381

[2]

Awad HA, 2000, J BIOMED MATER RES, V51, P233, DOI 10.1002/(SICI)1097-4636(200008)51:2<233::AID-JBM12>3.0.CO

[3]

2-B

[4]

BRUDER SP, 1998, CLIN ORTHOP RELAT R, V247, P335

[5]

The stiffness of bone marrow cell-knit composites is increased during mechanical load [J].

Bruinink, A ;

Siragusano, D ;

Ettel, G ;

Brandsberg, T ;

Brandsberg, F ;

Petitmermet, M ;

Müller, B ;

Mayer, J ;

Wintermantel, E .

BIOMATERIALS, 2001, 22 (23) :3169-3178

[6]

Adhesion of mammalian cells to polymer surfaces: from physical chemistry of surfaces to selective adhesion on defined patterns [J].

Dewez, JL ;

Lhoest, JB ;

Detrait, E ;

Berger, V ;

Dupont-Gillain, CC ;

Vincent, LM ;

Schneider, YJ ;

Bertrand, P ;

Rouxhet, PG .

BIOMATERIALS, 1998, 19 (16) :1441-1445

[7]

Understanding intercellular interactions and cell adhesion:: Lessons from studies on protein-metal interactions [J].

Eckert, R ;

Jeney, S ;

Hörber, JKH .

CELL BIOLOGY INTERNATIONAL, 1997, 21 (11) :707-713

[8]

GAO M, 2004, J BEIJING U CHEM TEC, V31, P67

[9]

Effect of osteoblastic culture conditions on the structure of poly(DL-lactic-co-glycolic acid) foam scaffolds [J].

Goldstein, AS ;

Zhu, GM ;

Morris, GE ;

Meszlenyi, RK ;

Mikos, AG .

TISSUE ENGINEERING, 1999, 5 (05) :421-433

[10]

BIOENGINEERING OF POLY(BETA-HYDROXYALKANOATES) FOR ADVANCED MATERIAL APPLICATIONS - INCORPORATION OF CYANO AND NITROPHENOXY SIDE-CHAIN SUBSTITUENTS [J].

KIM, OY ;

GROSS, RA ;

RUTHERFORD, DR .

CANADIAN JOURNAL OF MICROBIOLOGY, 1995, 41 :32-43

← 1 2 3 →