5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa

被引：35

作者：

Jiang, ZD ^{[1
]}

Ketchum, SO ^{[1
]}

Gerwick, WH ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 01期

关键词：

Rhodymenia pertusa; Rhodymeniaceae; marine algae; oxylipin; 5-lipoxygenase;

D O I：

10.1016/S0031-9422(99)00445-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid extract of the temperate red alga Rhodymenia pertusa has yielded four eicosanoid metabolites, three of which are new natural products. Using principally NMR and MS techniques, their structures were deduced as 5R,6S-dihydroxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid (5R,6S-diHETE), 5R*,6S*-dihydroxy-7(E),9(E),11(Z),14(Z),17(Z)-eicosapentaenoic acid (5R*,6S*-diHEPE), 5-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraeonic acid (5-HETE), 5-hydroxy-6(E),8(Z),11(Z),14(Z),17(Z)-eicosapentaenoic acid (5-HEPE). The co-occurrence of these metabolites strongly suggests that R. pertusa contains a unique 5R-lipoxygenase system acting on both arachidonic and eicosapentaenoic acids. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：129 / 133

页数：5

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