Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells

被引：94

作者：

Kim, HJ

Jang, SI

Kim, YJ

Chung, HT

Yun, YG

Kang, TH

Jeong, OS

Kim, YC ^{[1
]}

机构：

[1] Wonkwang Univ, Immunopia Res Lab Mol & Cellular Immunol, Iksan 570749, South Korea

[2] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

来源：

FITOTERAPIA | 2004年 / 75卷 / 3-4期

关键词：

scopoletin; prostaglandin E-2; cyclooxygenase-2;

D O I：

10.1016/j.fitote.2003.12.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Scopoletin (1-50 mug/ml) inhibited the release of PGE(2), TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE(2) production through the depression of COX-2 expression. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：261 / 266

页数：6

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