Optimization strategies for HPLC enantio separation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases

被引：109

作者：

Aboul-Enein, HY ^{[1
]}

Ali, M ^{[1
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC03, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia

来源：

FARMACO | 2002年 / 57卷 / 07期

关键词：

optimization; HPLC conditions; enantiomeric resolution; polysaccharides CSPs; macrocyclic glycopeptide antibiotic CSPs;

D O I：

10.1016/S0014-827X(02)01242-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The chiral. resolution by high performance liquid chromatography (HPLC) is controlled by a number of parameters. The optimization of HPLC parameters is an important issue in chiral resolution. This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs). The most important parameters discussed are composition of mobile phase, pH of mobile phase, flow rate, temperature and effect of other parameters. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：513 / 529

页数：17

共 46 条

[41] RESOLUTION OF ENANTIOMERIC AMIDES ON A CELLULOSE-BASED CHIRAL STATIONARY PHASE - STERIC AND ELECTRONIC EFFECTS [J].