A dividing matter: Drp1/Dnm1-independent mitophagy

被引：19

作者：

Graef, Martin ^{[1
,2
]}

机构：

[1] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respos, D-50931 Cologne, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 05期

关键词：

MITOCHONDRIAL FISSION; AUTOPHAGY; DEGRADATION; PARKIN; PROTEIN; ATG32; MACHINERY; REQUIRES; NETWORK; STRESS;

D O I：

10.1083/jcb.201611079

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial. In this issue, Yamashita et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605093) report that mitochondria! fragments start to bud and divide from mitochondrial tubules when in tight association with forming autophagosomes, but independently of the mitochondrial division factor Drp1/Dnm1.

引用

收藏

页码：599 / 601

页数：3

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