Fulminant hepatitis B following bone marrow transplantation in an HBsAg-negative, HBsAb-positive recipient; reactivation of dormant virus during the immunosuppressive period

被引：69

作者：

Iwai, K

Tashima, M

Itoh, M

Okazaki, T

Yamamoto, K

Ohno, H

Marusawa, H

Ueda, Y

Nakamura, T

Chiba, T

Uchiyama, T

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, Sakyo Ku, Kyoto 6068397, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto 6068397, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Clin Sci Pathol Organs, Kyoto 6068397, Japan

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / 01期

关键词：

bone marrow transplantation; hepatitis B; HBsAg-negative;

D O I：

10.1038/sj.bmt.1702093

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

It is widely accepted that seroconversion of HBsAg to HBsAb indicates clearance of hepatitis B virus. We describe a 50-year-old man with chronic myelocytic leukemia who developed lethal hepatitis B 22 months after allo-BMT. He had been negative for HBsAg and positive for HBsAb before BMT. Hepatitis B virus latently existing in the liver cells before BMT proliferated during the immunosuppressed period causing fatal hepatitis. Recipients with positive HBsAb should be considered to have the potential for active hepatitis B to emerge after BMT.

引用

页码：105 / 108

页数：4

共 14 条

[11] Hepatitis viruses and hematopoietic cell transplantation: A guide to patient and donor management [J].