C-aryl glycosides via tandem intramolecular benzyne-furan cycloadditions.: Total synthesis of vineomycinone B2 methyl ester

被引：72

作者：

Chen, Chi-Li ^{[1
]}

Sparks, Steven M. ^{[1
]}

Martin, Stephen F. ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 42期

关键词：

D O I：

10.1021/ja0652619

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A triply convergent total synthesis of vineomycinone B2 methyl ester has been achieved by an approach with a longest linear sequence of 16 steps. The synthesis features the use of silicon tethers as disposable linkers to control the regiochemistry in two tandem Diels-Alder reactions of substituted benzynes and glycosyl furans to provide rapid access to the fully intact anthrarufin core of vineomycinone B2 methyl ester. Copyright © 2006 American Chemical Society.

引用

页码：13696 / 13697

页数：2

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