Microvascular dysfunction in sepsis

被引:117
作者
Lush, CW
Kvietys, PR
机构
[1] London Hlth Sci Ctr, Vasc Biol Program, London, ON N6A 4G5, Canada
[2] Univ Western Ontario, Dept Physiol, London, ON N6A 4G5, Canada
关键词
vasoreactivity; tissue oxygenation; nitric oxide; adhesion molecules; leukocyte recruitment; vascular permeability;
D O I
10.1038/sj.mn.7300096
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The micorvascular dysfucntion which occurs in sepsis involves all three elements of the microcirculation:arterioles, capillaries, and venules. In sepsis, the arterioles are hyporesponsive to vasoconstrictors and vasodilators. Sepsis also reduces the number of perfused capillaries, therapy impacting on oxygen diffusion to mitochondria. In the venules of some tissues (e.g., mesentery) there is an inflammatory response characterized by neutrophil infiltration and protein leakage. In addition, PMN-endothelial adhesive interactions occur in precapillary microvessels and capillaries in organs, such as, the lung and heart. Thus, all these elements of the microcirculation are involved in the sepsis-induced inflammation. In this review we address emerging views on the mechanisms involved in the microvascular dysfunction induced by sepsis within the framework of these three basic elements of the microcirculatory.
引用
收藏
页码:83 / 101
页数:19
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